Bullous Pemphigoid, Psoriasis Linked to Increased Risk for Alzheimer Disease - Dermatology Advisor
Bullous pemphigoid and psoriasis may be associated with an increased risk for Alzheimer disease, and skin cancer may have a protective effect, according to study findings published in Clinical, Cosmetic and Investigational Dermatology . Researchers conducted a review of studies regarding the relationship between Alzheimer disease and bullous pemphigoid, hidradenitis suppurativa, psoriasis, skin cancer, and cutaneous amyloidosis. Some studies have reported an association between dementia and bullous pemphigoid, with a risk ratio (RR) ranging from 2.2 to 4.8. The investigators cited a Finnish study in 2016 that found an RR for bullous pemphigoid of 2.6 in patients with Alzheimer disease and an RR of 3.6 in patients with vascular dementia. A separate multi-centered, case-control study found decreased cognitive capability and a higher risk for cognitive impairment in patients with bullous pemphigoid and that these patients were more likely to develop dementia. Con...