Pseudomonas Aeruginosa Treatment

Scleroderma, or systemic sclerosis, remains the most challenging rheumatic disease to treat and holds the highest mortality rate. This review explores the unique pathophysiology, clinical features, and therapeutic approaches to this systemic connective tissue disease. During my near half-century of rheumatology practice, I found that scleroderma, or systemic sclerosis, to be the most challenging rheumatic disease to diagnose and manage. Its pathogenesis is less well-understood than other systemic connective tissue diseases – such as systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) – and this gap has impeded development of effective therapies. Further impacting management is the fact that systemic sclerosis (SSc) presents in a variety of ways, often resulting in consultation with myriad specialists, diagnostic confusion, and treatment delays. In this review, the many presentations of SSc will be illustrated with hypothetical case examples, as a means to exploring the di...

1. Plain language summary Key message The Commission on Human Medicines (CHM) has reviewed the available safety data for the use of the macrolide antibiotics erythromycin, clarithromycin and azithromycin during pregnancy. The available evidence is insufficient to confirm with certainty whether there is a small increased risk of malformations (birth defects) or miscarriage when macrolides are taken in early pregnancy. There remains a need for high-quality research into the effect of erythromycin, clarithromycin or azithromycin in pregnancy. Further data are needed to draw firm conclusions. Certain infections in pregnancy can cause serious harm to both to the mother and baby if not treated. In such cases, pregnant women should receive treatment with an appropriate antibiotic. Decisions by the prescriber of which antibiotic to use should be based on the benefits and risk to mother and baby. If a prescriber views that the potential benefits of treatment will outweigh...

Dark spots on the face can result from hyperpigmentation, which is a common skin condition that occurs when the skin produces too much melanin. Hyperpigmentation can be due to sun exposure, scarring, aging, and more. Many dark spots are harmless. However, if a person wants to reduce their appearance, they can usually do by using topical treatments. This article will look at dark spots that result from hyperpigmentation. It will discuss their causes, how to get rid of them, and some treatment options. It will also look at approaches and ingredients that people should avoid. Dark spots on the face can occur if the skin overproduces melanin, which is the pigment that gives skin its color. This is known as hyperpigmentation. Hyperpigmentation can develop as a result of: aging hormonal changes, such as during pregnancy or menopause sun exposure Skin damage can also cause post-inflammatory hyperpigmentation (PIH). People may develop PIH due to: acne bites, cuts, and burns excessive or incorr...

Development of new broad-spectrum antibiotics that are effective against both gram-positive and gram-negative bacteria could improve treatment choices for bacterial skin and skin structure infections (ABSSSIs). Ceftobiprole is an advanced-generation intravenous cephalosporin that has extensive in vitro efficacy against both gram-positive and gram-negative bacteria (including methicillin-resistant Staphylococcus aureus). The TARGET study compared ceftobiprole to vancomycin + aztreonam in a randomized, double-blind, active-controlled, parallel-group, multicenter, phase 3 noninferiority trial. Early clinical response 48–72 hours after treatment initiation in the intent-to-treat (ITT) population was the primary efficacy endpoint defined by the Food and Drug Administration. In contrast, the European Medicines Agency defined investigator-assessed clinical success at the test-of-cure (TOC) visit. The lower limit of the 95% CI for the difference in success rates (ceftobiprole versus vancomycin...

Colitis is an inflammation of the lining of the colon. Many conditions can cause colitis. If a person has colitis, they will have abdominal pain, discomfort, and diarrhea. People with colitis may experience mild chronic pain or severe and sudden pain. There are different types of colitis, and many have overlapping symptoms. This article looks at colitis, different types of colitis, causes, symptoms, and treatments. Colitis is an inflammation of the colon's lining. The large intestine can become inflamed for several different reasons. The most common causes typically include infection, such as: Both Crohn's disease and ulcerative colitis form the two major types of IBD. This condition typically affects people between 15–35 years of age, and then there is a second peak of the condition in people between 60–70 years of age. Colitis is often chronic, and there is no known cure. However, a person can receive treatment for the condition and effectively manage it. There are several t...

NewsDesk   @infectiousdiseasenews The Norwegian Institute of Public Health warns of an ongoing outbreak of the bacterium Pseudomonas aeruginosa in more than ten of the country's hospitals. Cases of infection have now been reported in three of the country's four health regions. Image/CDC The outbreak was discovered in November 2021 when three patients admitted to UNN Tromsø for covid-19 became seriously ill and died of blood poisoning with identical bacterial strains. Helse Nord then established an outbreak group, and so far they have identified a total of 11 patients with the same bacterial strain from different hospitals in the region. As part of national handling of such incidents, the National Institute of Public Health (NIPH) asked all health regions to investigate further whether they could identify patients associated with the outbreak. Infection has now been detected in another 15 patien...