Pseudomonas Aeruginosa Treatment

Group B Streptococcus (GBS) is a catalase-negative, gram-positive coccus that can cause many types of infections in humans. GBS is the most common cause of bacteremia, sepsis, pneumonia, and meningitis in newborns, with a 4% to 6% mortality rate. According to the Centers for Disease Control and Prevention (CDC), newborns are at higher risk for GBS infection if the mother carries the bacteria late in pregnancy. Thus, if pregnant women test positive on GBS screening, they receive intravenous (IV) antibiotics while giving birth to prevent vertical transmission of GBS to their newborn. The American Society for Microbiology provides antimicrobial prophylaxis against GBS based on the pregnant woman's allergic diagnosis or history. 1 Penicillin is recommended in patients with no penicillin allergy. For patients with penicillin allergies without a history of severe IgE-mediated hypersensitivity reactions, cefazolin is recommended instead of penicillin. For patients with a history of sever...

Abstract Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first publication on the clinical applications of phages. At the Center for Phage Biology & Therapy at Yale University, a preparatory modular approach has been established to offer safe and potent phages for single-patient investigational new drug applications while recognizing the time constraints imposed by infection(s). This study provides a practical walkthrough of the pipeline with an Autographiviridae phage targeting Pseudomonas aeruginosa (phage vB_PaeA_SB, abbreviated to ΦSB). Notably, a thorough phage characterization and the evolutionary selection pressure exerted on bacteria by phages, analogous to antibiotics, are incorporated into the pipeline. ...

At a Glance Taking the oral antibiotic doxycycline within three days after unprotected sex reduced the risk of sexually transmitted infections among those at increased risk. Further research is needed to test this preventive approach among varied populations and assess the potential risks.  Sexually transmitted infections (STIs), such as chlamydia, syphilis, and gonorrhea, have been on the rise nationwide. They disproportionally affect men who have sex with men and transgender women. Left untreated, they can lead to serious health issues, such as blindness, brain and nerve problems, and infertility in women. Condoms can block many STIs. But condoms are not always used consistently or correctly. So researchers have been exploring other options for preventing STIs, especially among those at elevated risk for repeated infections. Previous studies found evidence that the antibiotic doxycycline, taken shortly after sex, might reduce the risk of bacterial STIs amon...

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