New research: Vaccine against 3 encephalitis viruses found safe, effective - The Indian Express

A vaccine for eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV), and Venezuelan equine encephalitis virus (VEEV) was found to be safe, well-tolerated and induced a neutralising antibody response in adult volunteers, according to results from a phase 1 clinical trial, published in The Lancet Infectious Diseases.

EEEV, WEEV and VEEV are spread to humans through the bites of infected mosquitoes. Horses are also susceptible to infection, but horses cannot transmit the viruses directly to humans. Infections in humans are rare but can lead to flu-like symptoms and, in some cases, severe neurological damage or death.

Researchers designed a virus-like particle (VLP) vaccine candidate that uses proteins from the outer shells of the viruses, the US National Institutes of Health said in a media release. VLPs do not contain the genetic material that the viruses need to replicate inside cells, so VLPs cannot cause infection. In trials on 30 candidates, the vaccine was safe, well-tolerated and induced durable immune responses against all three viruses, the release said.

(Source: NIH, US)

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