Prevalence of Helicobacter Pylori Infection in RA Patients Who ... - Physician's Weekly

The following is a summary of "Frequency of Helicobacter pylori in Patients With Rheumatoid Arthritis Whose Methotrexate Was Stopped Due to Gastrointestinal Intolerance," published in the March 2023 issue of Rheumatology by Guloksuz, et al.

For a study, researchers sought to compare the frequency of Helicobacter pylori infection among patients with rheumatoid arthritis (RA) who experienced methotrexate (MTX)-related gastrointestinal system (GIS) intolerance and those without intolerance; second, to identify factors associated with MTX-related GIS intolerance.

The study analyzed data from 9,756 patients with RA who sought medical care between January 2011 and December 2020. MTX-related GIS intolerance was defined as the discontinuation of MTX due to dyspeptic symptoms despite supportive measures, and it was observed in 1,742 (31.3%) out of 5,572 MTX users. A total of 390 patients who underwent at least one gastroscopic evaluation were included in the final analysis. The demographic, clinical, laboratory, and pathologic characteristics of patients with and without MTX-related GIS intolerance were compared. Logistic regression analysis determined the factors associated with MTX-related GIS intolerance.

Among the 390 patients, 160 (41.0%) experienced MTX-related GIS intolerance. According to pathology results, the presence of H. pylori, inflammation, and activity was significantly higher in patients with MTX-related GIS intolerance (P < 0.001 for each comparison). In the multivariable logistic regression analysis, the use of biologic disease-modifying antirheumatic drugs (DMARDs) or targeted synthetic DMARDs, along with the presence of H. pylori, were identified as independently associated factors for MTX-related GIS intolerance (odds ratio [OR]: 3.03 for model 1; OR: 3.02 for model 2 for biologic/targeted synthetic DMARDs; OR: 9.13 for model 1; OR: 5.71 for model 2 for H. pylori presence).

The study revealed that the presence of H. pylori and the use of biologic or targeted synthetic DMARDs were associated with MTX-related GIS intolerance in patients with RA.

Source: journals.lww.com/jclinrheum/Abstract/2023/06000/Frequency_of_Helicobacter_pylori_in_Patients_With.2.aspx

Adblock test (Why?)

Comments

Post a Comment

Popular posts from this blog

Rashes that look like scabies: Causes, symptoms, and treatment - Medical News Today

Image
Scabies is a skin condition that occurs as the result of a mite known as Sarcoptes scabiei. The rash that results from scabies may appear similar to other skin conditions, such as psoriasis, eczema, or contact dermatitis. In this article, we look at what a scabies rash looks like. We also look at other rashes that are similar in appearance and their treatment options. Scabies is a common condition that occurs as the result of an infestation of a microscopic skin mite called Sarcoptes scabiei. The mites burrow under the skin, causing intense itching and a rash. The Centers for Disease Control and Prevention (CDC) describes the rash as pimple-like. On darker skin, the rash may be more difficult to see, but a person should be able to feel it. According to DermNet, a scabies rash is varied in appearance, and may appear as: pimple-like on the limbs and trunk widespread or coin-shaped small blisters scales lesions in the armpits, groin, navel, areolas, scrotum, buttocks, and along the penil...
Read more

Urinary Tract Infection (UTI): Causes, Symptoms & Treatment - Cleveland Clinic

Image
Can I prevent a urinary tract infection? The following lifestyle changes can help prevent urinary tract infections: Practice good hygiene Practicing good hygiene is one of the best ways to help prevent UTIs. This is especially important if you have a vagina because your urethra is much shorter, and it's easier for E. coli to move from your rectum back into your body. Always wipe from front to back after a bowel movement (pooping) to avoid this. During your menstrual cycle, it's also a good idea to regularly change your period products, including pads and tampons. You should also avoid using any deodorants on your vagina. Drink plenty of fluids Drinking extra fluids — especially water — each day can help flush out bacteria from your urinary tract. Healthcare providers recommend drinking six to eight glasses of water daily. Change your peeing habits Peeing can play a big role in getting rid of bacteria from your body. Your pee is a waste product, and each time you empty your bla...
Read more

Symtuza: Uses, side effects, alternatives, and more - Medical News Today

Image
The Food and Drug Administration (FDA) approves prescription drugs such as Symtuza to treat certain conditions. Symtuza is FDA-approved to treat HIV-1 in adults and children who weigh at least 40 kilograms (kg), which is about 88 pounds (lb). It's approved for people who: have just been diagnosed with HIV and haven't started treatment yet, OR are changing from another HIV treatment and: have been on a stable antiretroviral regimen for at least 6 months (this means you haven't had any changes to your HIV drugs for at least 6 months) have a viral load (the amount of HIV in your blood) that's less than 50 copies per milliliter (mL) have HIV that doesn't have mutations (changes) that could make it resistant (less likely to respond) to darunavir or tenofovir (two of the active drugs in Symtuza) HIV explained HIV stands for human immunodeficiency virus. There are two forms of this virus, HIV-1 and HIV-2. HIV-1 is the most common form. HIV is transmitted through body fluid...
Read more